Capsicum annuum Oleoresin Nanoemulgel - Design Characterization and In vitro Investigation of Anticancer and Antimicrobial Activities
- 作者: Eid A.1, Natsheh H.1, Issa L.1, Zoabi M.2, Amer M.2, Mahamid E.1, Mousa A.3
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隶属关系:
- Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University
- Department of Pharmacy, Faculty of Medicine and Health Sciences,, An-Najah National University
- Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University
- 期: 卷 30, 编号 2 (2024)
- 页面: 151-160
- 栏目: Immunology, Inflammation & Allergy
- URL: https://vestnikugrasu.org/1381-6128/article/view/645781
- DOI: https://doi.org/10.2174/0113816128283684231220062019
- ID: 645781
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Background::The use of naturally occurring bioactive materials is getting great attention owing to their safety and environmental properties. Oily compounds, known as oleoresins, are expected to provide an important source for the natural products industry aiming to develop novel treatments for skin conditions. In this work, Capsicum annuum oleoresin nanoemulgel formulations have been prepared and investigated for their antibacterial and anticancer properties.
Methodology::Several C. annuum oleoresin nanoemulgel formulations were prepared by incorporating a Carbopol 940 gel in a self-nanoemulsifying nanoemulsion consisting of C. annuum, tween 80, and span 80. The systems were characterized for particle size, polydispersity index (PDI), zeta potential, and rheology. The in vitro antimicrobial and cytotoxic activities of the optimum formulation were evaluated.
Results::The selected formulation is composed of 40% tween, 10% span 80, and 40% C. annuum oleoresin. This formulation produced a stable nanoemulsion with a narrow PDI value of 0.179 ± 0.08 and a droplet size of 104.0 ± 2.6 nm. Results of the in vitro antimicrobial studies indicated high potency of the systems against methicillin-resistant Staphylococcus aureus (MRSA) (zone of inhibition of 29 ± 1.9 mm), E. coli (33 ± 0.9 mm), K. pneumonia (30 ± 1.4 mm), and C. albicans (21 ± 1.5 mm), as compared to the reference antibiotic, ampicillin (18 ± 1.4 mm against K. pneumonia), and antifungal agent, fluconazole (12 ± 0.1 mm against C. albicans). Furthermore, cytotoxicity results, expressed as IC50 values, revealed that the oleoresin and its nanoemulgel had the best effects against the HepG2 cell line (IC50 value of 79.43 µg/mL for the nanoemulgel) and MCF7 (IC50 value of 57.54 µg/mL), and the most potent effect was found against 3T3 (IC50 value of 45.7 µg/m- L). On the other side, the system did not substantially exhibit activity against By-61 and Hela.
Conclusion::C. annuum oleoresin and its nanoemulgel can be considered valuable sources for the discovery of new antibacterial, antifungal, and anticancer compounds in the pharmaceutical industry, especially due to their potent activity against various cancer cell lines as well as bacterial and fungal strains.
作者简介
Ahmad Eid
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University
编辑信件的主要联系方式.
Email: info@benthamscience.net
Hiba Natsheh
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University
编辑信件的主要联系方式.
Email: info@benthamscience.net
Linda Issa
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University
Email: info@benthamscience.net
Majdulin Zoabi
Department of Pharmacy, Faculty of Medicine and Health Sciences,, An-Najah National University
Email: info@benthamscience.net
Monia Amer
Department of Pharmacy, Faculty of Medicine and Health Sciences,, An-Najah National University
Email: info@benthamscience.net
Effat Mahamid
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University
Email: info@benthamscience.net
Ahmed Mousa
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University
Email: info@benthamscience.net
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