The effect of space flight factors on the interaction of Escherichia coli with bacteriophage T7
- Authors: Sykilinda N.N.1, Lukianova A.A.1, Lavrikova V.V.2, Kutnik I.V.3, Panin N.V.4, Staritsyn N.A.2, Miroshnikov K.A.1
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Affiliations:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences
- JSC “BIOHIMMASH”
- Yu.A. Gagarin Research and Test Cosmonaut Training Center
- Lomonosov Moscow State University
- Issue: Vol 60, No 5 (2024)
- Pages: 499-506
- Section: Articles
- URL: https://vestnikugrasu.org/0555-1099/article/view/681857
- DOI: https://doi.org/10.31857/S0555109924050075
- EDN: https://elibrary.ru/QTICAK
- ID: 681857
Cite item
Abstract
For the first time, the interaction between bacteria and bacteriophage was studied under space conditions. The model system of E. coli and bacteriophage T7 was used. The results of the interaction depended on the duration of exposure of the system to space flight factors. During the first 2 days of microgravity exposure the virus replication rate in Space was higher than on Earth. The bacteria then have adapted to space conditions and acquired resistance to the bacteriophage, which persisted for 2 days after return to Earth. Over the next three days, the sensitivity of the E. coli to the T7 bacteriophage returned to its original level.
Keywords
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About the authors
N. N. Sykilinda
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences
Author for correspondence.
Email: sykilinda@mail.ru
Russian Federation, Moscow, 117997
A. A. Lukianova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences
Email: sykilinda@mail.ru
Russian Federation, Moscow, 117997
V. V. Lavrikova
JSC “BIOHIMMASH”
Email: sykilinda@mail.ru
Russian Federation, Moscow, 127299
I. V. Kutnik
Yu.A. Gagarin Research and Test Cosmonaut Training Center
Email: sykilinda@mail.ru
Russian Federation, Star City, Moscow region, 141160
N. V. Panin
Lomonosov Moscow State University
Email: sykilinda@mail.ru
Research Belozersky Institute of Physical and Chemical Biology
Russian Federation, Moscow, 119991N. A. Staritsyn
JSC “BIOHIMMASH”
Email: sykilinda@mail.ru
Russian Federation, Moscow, 127299
K. A. Miroshnikov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences
Email: sykilinda@mail.ru
Russian Federation, Moscow, 117997
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