Roles of AFAP1-AS1 in Gynecology and Urogenital System
- Authors: Qiu X.1, Huang Y.1, Jin L.1, Yang C.1, Wang J.1
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Affiliations:
- Department of Ultrasound, The Second Affiliated Hospital of Nanchang University
- Issue: Vol 30, No 8 (2024)
- Pages: 639-647
- Section: Immunology, Inflammation & Allergy
- URL: https://vestnikugrasu.org/1381-6128/article/view/646016
- DOI: https://doi.org/10.2174/0113816128286229240129090915
- ID: 646016
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Full Text
Abstract
Background:Human disease onset and progression are strongly associated with aberrant long noncoding RNA (lncRNA) expression, highlighting the functional regulatory role of lncRNA. Actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), a member of lncRNAs, is located on the antisense strand of Actin filament-associated protein 1 (AFAP1).
Methods:We conducted a comprehensive review of AFAP1-AS1's functions in gynecology and urogenital systems using the "PubMed" database.
Results:Our analysis reveals that AFAP1-AS1 is overexpressed and engages in the initiation and process of gynecological and urogenital diseases. The regulatory mechanisms employed by AFAP1-AS1 involve four major strategies: gene-level effects, competition for microRNA (miRNA) repression, protein binding, participation in signaling networks that influence cellular processes such as proliferative phenotype, migration, invasiveness, epithelial-mesenchymal transition (EMT), cycle regulation, drug resistance, and more. Furthermore, AFAP1-AS1 is implicated in guiding clinicopathological characteristics.
Conclusion:AFAP1-AS1 holds promise as a potent diagnostics and treatment option for gynecological and genitourinary systems in the future.
Keywords
About the authors
Xinyan Qiu
Department of Ultrasound, The Second Affiliated Hospital of Nanchang University
Email: info@benthamscience.net
Yulin Huang
Department of Ultrasound, The Second Affiliated Hospital of Nanchang University
Email: info@benthamscience.net
Lin Jin
Department of Ultrasound, The Second Affiliated Hospital of Nanchang University
Email: info@benthamscience.net
Canying Yang
Department of Ultrasound, The Second Affiliated Hospital of Nanchang University
Email: info@benthamscience.net
Jiwei Wang
Department of Ultrasound, The Second Affiliated Hospital of Nanchang University
Author for correspondence.
Email: info@benthamscience.net
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