Statin Therapy and Lipid Indices in Chronic Kidney Disease: A Systematic Review and Meta-analysis of Randomized Control Trials
- Authors: Karami J.1, Razi B.2, Imani D.3, Aslani S.4, Pakjoo M.5, Fasihi M.3, Mohammadi K.6, Sahebkar A.7
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Affiliations:
- Department of Laboratory Sciences,, Khomein University of Medical Sciences
- Department of Laboratory Sciences and Hematology, North Khorasan University of Medical Sciences
- Department of Immunology, School of Public Health,, Tehran University of Medical Sciences
- Centre for Innate Immunity and Infectious Diseases,, Hudson Institute of Medical Research
- Department of Hematology, Faculty of Medicine,, Tarbiat Modares University
- Department of Clinical Pharmacy, Faculty of Pharmacy,, Tehran University of Medical Sciences
- Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences
- Issue: Vol 30, No 5 (2024)
- Pages: 362-376
- Section: Immunology, Inflammation & Allergy
- URL: https://vestnikugrasu.org/1381-6128/article/view/645997
- DOI: https://doi.org/10.2174/0113816128285148240122112045
- ID: 645997
Cite item
Full Text
Abstract
Background:Several studies have demonstrated the improvement in serum lipoproteins by statins in patients with Chronic Kidney Diseases (CKDs), including End-Stage Renal Disease (ESRD). However, the results of these studies are inconclusive.
Aims:We aimed to systematically investigate the effect of statins on lipid profiles of patients with CKD by performing a meta-analysis of Randomized Controlled Trials (RCTs).
Methods:Major electronic databases (Scopus, MEDLINE/PubMed, and ISI Web of Science) were searched from inception to August, 2023, to find randomized controlled trials (RCTs) evaluating the effect of different statins on serum lipoproteins in CKD patients. Weighted Mean Difference (WMD) with 95% Confidence Intervals (CI) was used to estimate the effect size. Trial Sequential Analysis (TSA) was performed to confirm the robustness of the evidence.
Results:A total of 18 publications were identified. It was found that statins reduced serum levels of Low-Density Lipoprotein (LDL)-C (WMD = -27.81 mg/dl, 95% CI = -34.47 to -21.15, p < 0.001) and total cholesterol (WMD = -25.44 mg/dl, 95% CI = -34.71 to -16.18, p < 0.001) in patients with CKD compared to the control group. Nonetheless, the effect of statins on High-Density Lipoprotein (HDL)-C (WMD = 0.57 mg/dl, 95% CI = -0.71 to 1.85, P = 0.38) and Triglyceride (TG) (WMD = -9.08 mg/dl, 95% CI = -22.22 to 2.06, P = 0.11) was not statistically significant. The results of TSA confirmed the robustness of the evidence and were consistent with the pooled effect size. The findings of subgroup analysis and time response analysis were also significant.
Conclusion:It was found that statin therapy reduced the levels of LDL-C and total cholesterol in patients with CKD.
About the authors
Jafar Karami
Department of Laboratory Sciences,, Khomein University of Medical Sciences
Email: info@benthamscience.net
Bahman Razi
Department of Laboratory Sciences and Hematology, North Khorasan University of Medical Sciences
Email: info@benthamscience.net
Danyal Imani
Department of Immunology, School of Public Health,, Tehran University of Medical Sciences
Author for correspondence.
Email: info@benthamscience.net
Saeed Aslani
Centre for Innate Immunity and Infectious Diseases,, Hudson Institute of Medical Research
Email: info@benthamscience.net
Mahdi Pakjoo
Department of Hematology, Faculty of Medicine,, Tarbiat Modares University
Email: info@benthamscience.net
Mahdieh Fasihi
Department of Immunology, School of Public Health,, Tehran University of Medical Sciences
Email: info@benthamscience.net
Keyhan Mohammadi
Department of Clinical Pharmacy, Faculty of Pharmacy,, Tehran University of Medical Sciences
Email: info@benthamscience.net
Amirhossein Sahebkar
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences
Author for correspondence.
Email: info@benthamscience.net
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