Interplay between LncRNA/miRNA and TGF-β Signaling in the Tumorigenesis of Gynecological Cancer


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Abstract

Gynecologic cancers are among the most common malignancies with aggressive features and poor prognosis. Tumorigenesis in gynecologic cancers is a complicated process that is influenced by multiple factors, including genetic mutations that activate various oncogenic signaling pathways, including the TGF-β pathway. Aberrant activation of TGF-β signaling is correlated with tumor recurrence and metastasis. It has been shown that non-coding RNAs (ncRNAs) have crucial effects on cancer cell proliferation, migration, and metastasis. Upregulation of various ncRNAs, including long non-coding RNAs (lncRNA) and microRNAs (miRNAs), has been reported in several tumors, like cervical, ovarian, and endometrial cancers, but their cellular mechanisms remain to be investigated. Thus, recognizing the role of ncRNAs in regulating the TGF-β pathway may provide novel strategies for better treatment of cancer patients. The present study summarizes recent findings on the role of ncRNAs in regulating the TGF-β signaling involved in tumor progression and metastasis in gynecologic cancers.

About the authors

Pegah Safavi

Department of Medical Radiation,, Islamic Azad University, Science and Research Branch

Email: info@benthamscience.net

Kimia Moghadam

Department of Medicinal Chemistry, Faculty of Pharmacy, Zabol University of Medical Sciences

Email: info@benthamscience.net

Zahra Haghighi

Department of Clinical Biochemistry, Kashmar School of Medical Sciences, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Gordon Ferns

Division of Medical Education, Brighton and Sussex Medical School

Email: info@benthamscience.net

Farzad Rahmani

Department of Clinical Biochemistry, Kashmar School of Medical Sciences,, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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