Naringin Affects Caspase-3, IL-1β, and HIF-1α Levels in Experimental Kidney Ischemia-Reperfusion in Rats
- Авторы: Danis E.1, Acar G.2, Dasdelen D.3, Solmaz M.4, Mogulkoc R.2, Baltaci A.2
-
Учреждения:
- Department of Physiology, Medical Faculty,, Selcuk University,
- Department of Physiology, Medical Faculty, Selçuk University
- Department of Physiology, Medical Faculty,, Karamanoglu Mehmetbey University
- Department of Histology, Medical Faculty,, Selçuk University
- Выпуск: Том 30, № 42 (2024)
- Страницы: 3339-3349
- Раздел: Immunology, Inflammation & Allergy
- URL: https://vestnikugrasu.org/1381-6128/article/view/645990
- DOI: https://doi.org/10.2174/0113816128324562240816095551
- ID: 645990
Цитировать
Полный текст
Аннотация
Background:Microvascular dysfunction develops in tissues after Ischemia-Reperfusion (IR). The current study aimed to determine the effect of naringin supplementation on kidney caspase-3, IL-1β, and HIF-1α levels and kidney histology in rats undergoing unilateral nephrectomy and kidney-ischemia reperfusion.
Methods:The study was conducted on 8-12 weeks old 40 Wistar-type male rats. Experimental renal ischemia- reperfusion and unilateral nephrectomy were performed under general anesthesia in rats. Experimental groups were formed as follows: 1-Control group, 2-Sham control + Vehicle group, 3- Renal ischemia-reperfusion (Renal I+R) + Vehicle group, 4-Renal I+R + Naringin (50 mg/kg/day) group (3 days application) group, 5-Renal I+R + Naringin (100 mg/kg/day) group (3 days supplementation). Nephrectomy in the left kidneys and the ischemia for 45 minutes and reperfusion in the right kidneys followed by 72 hours of reperfusion. Naringin was administered intraperitoneally at the beginning of the reperfusion, 24 hours and 48 hours later. At the end of the experiments, blood was first taken from the heart in animals under general anesthesia. Then, the animals were killed by cervical dislocation, and kidney tissue samples were taken. Tissues were evaluated for caspase-3, IL-1β, and HIF-1α as well as histologically.
Results:As a result of ischemia in kidney tissues, HIF-1α decreased, while caspase-3 and IL-1β increased. IR also caused damage to the kidney tissue. However, naringin supplementation corrected the deterioration to a certain extent.
Conclusion:The results of the study showed that naringin may have protective effects on kidney damage due to anti-inflammatory and antiapoptosis mechanisms caused by unilateral nephrectomy and IR in rats.
Об авторах
Esra Danis
Department of Physiology, Medical Faculty,, Selcuk University,
Email: info@benthamscience.net
Gozde Acar
Department of Physiology, Medical Faculty, Selçuk University
Email: info@benthamscience.net
Dervis Dasdelen
Department of Physiology, Medical Faculty,, Karamanoglu Mehmetbey University
Email: info@benthamscience.net
Merve Solmaz
Department of Histology, Medical Faculty,, Selçuk University
Email: info@benthamscience.net
Rasim Mogulkoc
Department of Physiology, Medical Faculty, Selçuk University
Автор, ответственный за переписку.
Email: info@benthamscience.net
Abdulkerim Baltaci
Department of Physiology, Medical Faculty, Selçuk University
Email: info@benthamscience.net
Список литературы
- Giaccia AJ, Simon MC, Johnson R. The biology of hypoxia: The role of oxygen sensing in development, normal function, and disease. Genes Dev 2004; 18(18): 2183-94. doi: 10.1101/gad.1243304 PMID: 15371333
- Giordano FJ. Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 2005; 115(3): 500-8. doi: 10.1172/JCI200524408 PMID: 15765131
- Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 2006; 17(6): 1503-20. doi: 10.1681/ASN.2006010017 PMID: 16707563
- Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Ischemia/Reperfusion. Compr Physiol 2016; 7(1): 113-70. doi: 10.1002/cphy.c160006 PMID: 28135002
- Wu Y, Chen W, Zhang Y, et al. Potent therapy and transcriptional profile of combined erythropoietin-derived peptide cyclic helix B surface peptide and caspase-3 siRNA against kidney ischemia/reperfusion injury in mice. J Pharmacol Exp Ther 2020; 375(1): 92-103. doi: 10.1124/jpet.120.000092 PMID: 32759272
- Dinarello CA. An expanding role for interleukin-1 blockade from gout to cancer. Mol Med 2014; 20(S1) (Suppl. 1): S43-58. doi: 10.2119/molmed.2014.00232 PMID: 25549233
- Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: Back to the future. Immunity 2013; 39(6): 1003-18. doi: 10.1016/j.immuni.2013.11.010 PMID: 24332029
- Cordero MD, Alcocer-Gómez E, Ryffel B. Gain of function mutation and inflammasome driven diseases in human and mouse models. J Autoimmun 2018; 91: 13-22. doi: 10.1016/j.jaut.2018.03.002 PMID: 29610014
- Liu Z, Meng Y, Miao Y, Yu L, Yu Q. Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis. Aging (Albany NY) 2021; 13(1): 865-76. doi: 10.18632/aging.202191 PMID: 33260147
- Zeng X, Su W, Zheng Y, et al. Pharmacokinetics, tissue distribution, metabolism, and excretion of naringin in aged rats. Front Pharmacol 2019; 10: 34. doi: 10.3389/fphar.2019.00034 PMID: 30761003
- Amini N, Sarkaki A, Dianat M, Mard SA, Ahangarpour A, Badavi M. Naringin and trimetazidine improve baroreflex sensitivity and nucleus tractus solitarius electrical activity in renal ischemia-reperfusion injury. Arq Bras Cardiol 2021; 117(2): 290-7. doi: 10.36660/abc.20200121 PMID: 34495221
- Liu L, Zhang P, Bai M, et al. p53 upregulated by HIF-1α promotes hypoxia-induced G2/M arrest and renal fibrosis in vitro and in vivo. J Mol Cell Biol 2019; 11(5): 371-82. doi: 10.1093/jmcb/mjy042 PMID: 30032308
- Shan Y, Chen D, Hu B, et al. Allicin ameliorates renal ischemia/ reperfusion injury via inhibition of oxidative stress and inflammation in rats. Biomed Pharmacother 2021; 142: 112077. doi: 10.1016/j.biopha.2021.112077 PMID: 34426252
- Wang R, Wu G, Dai T, et al. Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation. Exp Ther Med 2020; 21(1): 66. doi: 10.3892/etm.2020.9498 PMID: 33365066
- Khalid U, Pino-Chavez G, Nesargikar P, et al. Kidney ischaemia reperfusion injury in the rat: The EGTI scoring system as a valid and reliable tool for histological assessment. J Histol Histopathol 2016; 3(1): 1. doi: 10.7243/2055-091X-3-1
- Liu H, Li Y, Xiong J. The role of hypoxia-inducible factor-1 alpha in renal disease. Molecules 2022; 27(21): 7318. doi: 10.3390/molecules27217318 PMID: 36364144
- Movafagh S, Crook S, Vo K. Regulation of hypoxia-inducible factor-1a by reactive oxygen species: New developments in an old debate. J Cell Biochem 2015; 116(5): 696-703. doi: 10.1002/jcb.25074 PMID: 25546605
- Agarwal A, Nick HS. Renal response to tissue injury: Lessons from heme oxygenase-1 GeneAblation and expression. J Am Soc Nephrol 2000; 11(5): 965-73. doi: 10.1681/ASN.V115965 PMID: 10770977
- Moore E, Bellomo R. Erythropoietin (EPO) in acute kidney injury. Ann Intensive Care 2011; 1(1): 3. doi: 10.1186/2110-5820-1-3 PMID: 21906325
- Schietke R, Warnecke C, Wacker I, et al. The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: Insights into cellular transformation processes mediated by HIF-1. J Biol Chem 2010; 285(9): 6658-69. doi: 10.1074/jbc.M109.042424 PMID: 20026874
- Warnecke C, Zaborowska Z, Kurreck J, et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells. FASEB J 2004; 18(12): 1462-4. doi: 10.1096/fj.04-1640fje PMID: 15240563
- Li P, Liu Y, Qin X, et al. SIRT1 attenuates renal fibrosis by repressing HIF-2α. Cell Death Discov 2021; 7(1): 59. doi: 10.1038/s41420-021-00443-x PMID: 33414425
- Pan SY, Tsai PZ, Chou YH, et al. Kidney pericyte hypoxia-inducible factor regulates erythropoiesis but not kidney fibrosis. Kidney Int 2021; 99(6): 1354-68. doi: 10.1016/j.kint.2021.01.017 PMID: 33812664
- Tanaka T, Wiesener M, Bernhardt W, Eckardt KU, Warnecke C. The human HIF (hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem J 2009; 424(1): 143-51. doi: 10.1042/BJ20090120 PMID: 19694616
- Kimura K, Iwano M, Higgins DF, et al. Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol 2008; 295(4): F1023-9. doi: 10.1152/ajprenal.90209.2008 PMID: 18667485
- Baumann B, Hayashida T, Liang X, Schnaper HW. Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3. Kidney Int 2016; 90(4): 797-808. doi: 10.1016/j.kint.2016.05.026 PMID: 27503806
- Meng F. A novel role of HIF-1α/PROX-1/LYVE-1 axis on tissue regeneration after renal ischaemia/reperfusion in mice. Arch Physiol Biochem 2019; 125(4): 321-31. doi: 10.1080/13813455.2018.1459728 PMID: 29633855
- Han M, Li S, Xie H, et al. Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 2021; 320(3): F308-21. doi: 10.1152/ajprenal.00577.2020 PMID: 33427060
- Cienfuegos-Pecina E, Ibarra-Rivera TR, Saucedo AL, et al. Effect of sodium ( S )-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway. PeerJ 2020; 8: e9438. doi: 10.7717/peerj.9438 PMID: 32728491
- Yan B, Min SJ, Xu B, et al. The protective effects of exogenous spermine on renal ischemia-reperfusion injury in rats. Transl Androl Urol 2021; 10(5): 2051-66. doi: 10.21037/tau-21-280 PMID: 34159086
- Li BY, Liu Y, Li ZH, et al. Dexmedetomidine promotes the recovery of renal function and reduces the inflammatory level in renal ischemia-reperfusion injury rats through PI3K/Akt/HIF-1α signaling pathway. Eur Rev Med Pharmacol Sci 2020; 24(23): 12400-7. doi: 10.26355/eurrev_202012_24035 PMID: 33336761
- Barakat M, Hussein AM, Salama MF, et al. Possible underlying mechanisms for the renoprotective effect of retinoic acid-pretreated Whartons jelly mesenchymal stem cells against renal ischemia/reperfusion injury. Cells 2022; 11(13): 1997. doi: 10.3390/cells11131997 PMID: 35805083
- Zhang B, Wan S, Liu H, et al. Naringenin alleviates renal ischemia reperfusion injury by suppressing ER stress-induced pyroptosis and apoptosis through activating Nrf2/HO-1 signaling pathway. Oxid Med Cell Longev 2022; 2022: 1-24. doi: 10.1155/2022/5992436 PMID: 36262286
- El-Sayed SS, Shahin RM, Fahmy A, Elshazly SM. Quercetin ameliorated remote myocardial injury induced by renal ischemia/reperfusion in rats: Role of Rho-kinase and hydrogen sulfide. Life Sci 2021; 287: 120144. doi: 10.1016/j.lfs.2021.120144 PMID: 34785193
- Zhang S, Xu X, Huang Y, et al. Anisodamine ameliorates ischemia/reperfusion-induced renal injury in rats through activation of the extracellular signal-regulated kinase (ERK) pathway and anti-apoptotic effect. Pharmazie 2021; 76(5): 220-4. doi: 10.1691/ph.2021.1302 PMID: 33964996
- Wang ZS, Zhou HH, Han Q, Guo YL, Li ZY. Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia reperfusion in mice. Acta Cirúrgica Brasileira 35 2020.
- Meng X, Wei M, Wang D, et al. The protective effect of hesperidin against renal ischemia-reperfusion injury involves the TLR-4/NF-κB/iNOS pathway in rats. Physiol Int 2020; 107(1): 82-91. doi: 10.1556/2060.2020.00003 PMID: 32491283
- Liu Y, Shi B, Li Y, Zhang H. Protective effect of luteolin against renal ischemia/reperfusion injury via modulation of pro-inflammatory cytokines, oxidative stress and apoptosis for possible benefit in kidney transplant. Med Sci Monit 2017; 23: 5720-7. doi: 10.12659/MSM.903253 PMID: 29196613
- Rider P, Carmi Y, Voronov E, Apte RN. Interleukin-1α. Semin Immunol 2013; 25(6): 430-8. doi: 10.1016/j.smim.2013.10.005
- Kezić A, Stajic N, Thaiss F. Innate immune response in kidney ischemia/reperfusion injury: Potential target for therapy. J Immunol Res 2017; 2017: 1-10. doi: 10.1155/2017/6305439 PMID: 28676864
- Aal-Aaboda M, Abu Raghif AR, Hadi NR. Effect of lipopolysaccharide from Rhodobacter sphaeroides on inflammatory pathway and oxidative stress in renal ischemia/reperfusion injury in male rats. Arch Razi Inst 2021; 76(4): 1013-24. doi: 10.22092/ari.2021.356003.1761 PMID: 35096337
- Mozaffari Godarzi S, Valizade Gorji A, Gholizadeh B, Mard SA, Mansouri E. Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion. Nefrología (English Edition) 2020; 40(3): 311-9. doi: 10.1016/j.nefroe.2020.06.017 PMID: 31892486
- Perez-Meseguer J, Torres-González L, Gutiérrez-González JA, et al. Anti-inflammatory and nephroprotective activity of Juglans mollis against renal ischemiareperfusion damage in a Wistar rat model. BMC Complement Altern Med 2019; 19(1): 186. doi: 10.1186/s12906-019-2604-7 PMID: 31349827
- Ahmed S, Khan H, Aschner M, Hasan MM, Hassan STS. Therapeutic potential of naringin in neurological disorders. Food Chem Toxicol 2019; 132: 110646. doi: 10.1016/j.fct.2019.110646 PMID: 31252025
- Raja Kumar S, Mohd Ramli ES, Abdul Nasir NA, Ismail NHM, Mohd Fahami NA. Preventive effect of naringin on metabolic syndrome and its mechanism of action: A systematic review. Evid Based Complement Alternat Med 2019; 2019: 1-11. doi: 10.1155/2019/9752826 PMID: 30854019
- Heidary Moghaddam R, Samimi Z, Moradi SZ, Little PJ, Xu S, Farzaei MH. Naringenin and naringin in cardiovascular disease prevention: A preclinical review. Eur J Pharmacol 2020; 887: 173535. doi: 10.1016/j.ejphar.2020.173535 PMID: 32910944
- Zeng X, Su W, Liu B, Chai L, Shi R, Yao H. A review on the pharmacokinetic properties of naringin and its therapeutic efficacies in respiratory diseases. Mini Rev Med Chem 2020; 20(4): 286-93. doi: 10.2174/1389557519666191009162641 PMID: 32134369
- Salehi B, Fokou PVT, Sharifi-Rad M, et al. The therapeutic potential of naringenin: A review of clinical trials. Pharmaceuticals (Basel) 2019; 12(1): 11. doi: 10.3390/ph12010011 PMID: 30634637
- Amini N, Sarkaki A, Dianat M, Mard SA, Ahangarpour A, Badavi M. Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation. Pharmacol Rep 2019; 71(6): 1059-66. doi: 10.1016/j.pharep.2019.06.007 PMID: 31604166
- Nielsen PM, Eldirdiri A, Bertelsen LB, Jørgensen HS, Ardenkjaer-Larsen JH, Laustsen C. Fumarase activity: An in vivo and in vitro biomarker for acute kidney injury. Sci Rep 2017; 7(1): 40812. doi: 10.1038/srep40812 PMID: 28094329
- Chihanga T, Ma Q, Nicholson JD, et al. NMR spectroscopy and electron microscopy identification of metabolic and ultrastructural changes to the kidney following ischemia-reperfusion injury. Am J Physiol Renal Physiol 2018; 314(2): F154-66. doi: 10.1152/ajprenal.00363.2017 PMID: 28978534
- Shi X, Wu Y, Li E, et al. The inhibitory effects of naringin in a rat model of postoperative intraperitoneal adhesion formation. Evid Based Complement Alternat Med 2022; 2022: 1-10. doi: 10.1155/2022/5331537 PMID: 35069760
- Li F, Zhan Z, Qian J, Cao C, Yao W, Wang N. Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway-mediated inhibition of apoptosis, oxidative stress and autophagy. Exp Ther Med 2021; 22(2): 811. doi: 10.3892/etm.2021.10243 PMID: 34131434
Дополнительные файлы
