Weight, CYP3A5 Genotype, and Voriconazole Co-administration Influence Tacrolimus Initial Dosage in Pediatric Lung Transplantation Recipients with Low Hematocrit based on a Simulation Model
- Авторлар: Hu K.1, Pan J.2, Qu W.3, He S.4, Yang Y.5, Shi H.1, Zhang Y.1, Chen X.6, Wang D.1
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Мекемелер:
- Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy, Xuzhou Medical University
- Department of Thoracic Cardiovascular Surgery, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University
- Department of General Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University
- Department of Pharmacy, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University
- Department of Pharmacy, The Affiliated Changzhou Childrens Hospital of Nantong University
- School of Nursing, Xuzhou Medical University
- Шығарылым: Том 30, № 34 (2024)
- Беттер: 2736-2748
- Бөлім: Immunology, Inflammation & Allergy
- URL: https://vestnikugrasu.org/1381-6128/article/view/645942
- DOI: https://doi.org/10.2174/0113816128318672240807112413
- ID: 645942
Дәйексөз келтіру
Толық мәтін
Аннотация
Objective:The method of administering the initial doses of tacrolimus in recipients of pediatric lung transplantation, especially in patients with low hematocrit, is not clear. The present study aims to explore whether weight, CYP3A5 genotype, and voriconazole co-administration influence tacrolimus initial dosage in recipients of pediatric lung transplantation with low hematocrit based on safety and efficacy using a simulation model.
Methods:The present study utilized the tacrolimus population pharmacokinetic model, which was employed in lung transplantation recipients with low hematocrit.
Results:For pediatric lung transplantation recipients not carrying CYP3A5*1 and without voriconazole, the recommended tacrolimus doses for weights of 10-13, 13-19, 19-22, 22-35, 35-38, and 38-40 kg are 0.03, 0.04, 0.05, 0.06, 0.07, and 0.08 mg/kg/day, which are split into two doses, respectively. For pediatric lung transplantation recipients carrying CYP3A5*1 and without voriconazole, the recommended tacrolimus doses for weights of 10-18, 18-30, and 30-40 kg are 0.06, 0.08, 0.11 mg/kg/day, which are split into two doses, respectively. For pediatric lung transplantation recipients not carrying CYP3A5*1 and with voriconazole, the recommended tacrolimus doses for weights of 10-20 and 20-40 kg are 0.02 and 0.03 mg/kg/day, which are split into two doses, respectively. For pediatric lung transplantation recipients carrying CYP3A5*1 and with voriconazole, the recommended tacrolimus doses for weights of 10-20, 20-33, and 33-40 kg are 0.03, 0.04, and 0.05 mg/kg/day, which are split into two doses, respectively.
Conclusion:The present study is the first to recommend the initial dosages of tacrolimus in recipients of pediatric lung transplantation with low hematocrit using a simulation model.
Негізгі сөздер
Авторлар туралы
Ke Hu
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy, Xuzhou Medical University
Email: info@benthamscience.net
Jia-Jun Pan
Department of Thoracic Cardiovascular Surgery, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University
Email: info@benthamscience.net
Wen-Qian Qu
Department of General Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University
Email: info@benthamscience.net
Su-Mei He
Department of Pharmacy, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University
Хат алмасуға жауапты Автор.
Email: info@benthamscience.net
Yang Yang
Department of Pharmacy, The Affiliated Changzhou Childrens Hospital of Nantong University
Хат алмасуға жауапты Автор.
Email: info@benthamscience.net
Hao-Zhe Shi
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy, Xuzhou Medical University
Email: info@benthamscience.net
Yi-Jia Zhang
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy, Xuzhou Medical University
Email: info@benthamscience.net
Xiao Chen
School of Nursing, Xuzhou Medical University
Хат алмасуға жауапты Автор.
Email: info@benthamscience.net
Dong-Dong Wang
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy, Xuzhou Medical University
Хат алмасуға жауапты Автор.
Email: info@benthamscience.net
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