Role of Natural Products against the Spread of SARS-CoV-2 by Inhibition of ACE-2 Receptor: A Review


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Abstract


A unique extreme acute breathing syndrome emerged in China and spread rapidly globally due to a newly diagnosed human coronavirus and declared a pandemic. COVID-19 was formally named by WHO, and the Global Committee on Taxonomy referred to it as extreme Acute respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Currently there is no efficient method to control the extent of SARS-CoV-2 other than social distancing and hygiene activities. This study aims to present a simple medicinal strategy for combating fatal viral diseases like COVID-19 with minimum effort and intervention. Different Ayurveda medicines (Curcuma longa, green tea, and Piper nigrum) inhibit virus entrance and pathogen transmission while also enhancing immunity. Piperine (1-piperoylpiperidine), as well as curcumin, combine to create an intermolecular complex (π- π) that improves curcumin bioavailability by inhibiting glucuronidation of curcumin in the liver. The receptor- binding domains of the S-protein and also the angiotensin-converting enzyme 2 receptor of the recipient organism are directly occupied by curcumin and catechin, respectively, thereby preventing viruses from entering the cell. As a result, the infection will be tolerated by the animal host.

About the authors

Krishana Sharma

Teerthanker Mahaveer College of Pharmacy, TeerthaTeerthanker Mahaveer University

Email: info@benthamscience.net

Shoma Devi

Department of Zoology, Krishna College of Science & Information Technology

Email: info@benthamscience.net

Dharmendra Kumar

Science Branch, Deendayal Upadhyay Institute of Archaeology, Archaeological Survey of India

Email: info@benthamscience.net

Zeeshan Ali

Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University

Email: info@benthamscience.net

Nishat Fatma

Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University

Email: info@benthamscience.net

Raghvendra Misra

Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University

Email: info@benthamscience.net

Gajendra Kumar

Department of Chemistry, Constituent Government College, MJP Rohilkhand University

Author for correspondence.
Email: info@benthamscience.net

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