A Quest for Potential Role of Vitamin D in Type II Diabetes Mellitus Induced Diabetic Kidney Disease


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Abstract

:Diabetes mellitus is a metabolic disorder characterized by high blood sugar levels. In recent years, T2DM has become a worldwide health issue due to an increase in incidence and prevalence. Diabetic kidney disease (DKD) is one of the devastating consequences of diabetes, especially owing to T2DM and the key clinical manifestation of DKD is weakened renal function and progressive proteinuria. DKD affects approximately 1/3rd of patients with diabetes mellitus, and T2DM is the predominant cause of end-stage kidney disease (ESKD). Several lines of studies have observed the association between vitamin D deficiency and the progression and etiology of type II diabetes mellitus. Emerging experimental evidence has shown that T2DM is associated with various kinds of kidney diseases. Recent evidence has also shown that an alteration in VDR (vitamin D receptor) signaling in podocytes leads to DKD. The present review aims to examine vitamin D metabolism and its correlation with T2DM. Furthermore, we discuss the potential role of vitamin D and VDR in diabetic kidney disease.

About the authors

Ahmad Obaid

Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm al-Qura University

Author for correspondence.
Email: info@benthamscience.net

Wesam Farrash

Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University

Email: info@benthamscience.net

Abdulrahman Mujalli

Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences,, Umm Al-Qura University

Email: info@benthamscience.net

Sandeep Singh

Department of Biomedical, Indian Scientific Education and Technology Foundation

Author for correspondence.
Email: info@benthamscience.net

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