Nephroprotective Effect of Ferula assa-foetida Oleo Gum Resin on Type 2 Diabetic Rats


Cite item

Full Text

Abstract

Objective:Diabetic nephropathy is one of the main causes of kidney failure in the end stage of diabetes worldwide. On the other hand, asafoetida is a gum whose hypoglycemic effects have been proven. The present study was conducted with the aim of using asafoetida to prevent diabetic nephropathy.

Methods:Diabetes was induced by a high-fat diet (60%) and streptozotocin injection (35 mg/kg) in rats. Diabetic rats were treated with an oral dose of 50 mg/kg of asafoetida for 8 weeks. At the end of the experiment, serum and urine parameters were examined. Antioxidant enzymes and lipid peroxidation levels in the kidney were also determined along with its histological examination. The expression levels of tumor necrosis factor-alpha and Transforming growth factor beta genes were also evaluated.

Results:Glucose, cholesterol, triglyceride, and HbA1c concentrations were significantly reduced in the asafoetida 50. On the other hand, in the treatment group, serum creatinine, urea, and albumin levels decreased and increased in urine. Antioxidant enzymes in the kidney improved significantly, and the expression of tumour necrosis factor-alpha and transforming growth factor-beta genes decreased. Histopathological examination also showed that necrosis, epithelial damage, and leukocyte infiltration increased in the diabetic and decreased in the treatment group.

Conclusion:The result of biochemical analysis, enzymatic, and histological examinations showed that asafoetida may delay the progression of diabetic nephropathy due to the presence of anti-inflammatory and antioxidant activities.

About the authors

Seyyed Bagheri

Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences

Email: info@benthamscience.net

Elham Hakimizadeh

Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences

Email: info@benthamscience.net

Mohammad Allahtavakoli

Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

References

  1. Sun H, Saeedi P, Karuranga S, et al. IDF diabetes atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 2022; 183: 109119. doi: 10.1016/j.diabres.2021.109119 PMID: 34879977
  2. Magliano DJ, Chen L, Carstensen B, et al. Trends in all-cause mortality among people with diagnosed diabetes in high-income settings: A multicountry analysis of aggregate data. Lancet Diabetes Endocrinol 2022; 10(2): 112-9. doi: 10.1016/S2213-8587(21)00327-2 PMID: 35026157
  3. Matoori S. Diabetes and its complications. ACS Pharmacol Transl Sci 2022; 5(8): 513-5. doi: 10.1021/acsptsci.2c00122 PMID: 35983272
  4. Gross JL, de Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T. Diabetic nephropathy: Diagnosis, prevention, and treatment. Diabetes Care 2005; 28(1): 164-76. doi: 10.2337/diacare.28.1.164 PMID: 15616252
  5. Mansour AE, Abdelmoniem RO, Elbadawy AM, Ibrahim WM. The utility of estimation of glomerular filtration rate by serum cystatin C as a predictor of diabetic kidney disease in both type I and type II diabetic patients: A single center study. Egypt J Intern Med 2023; 35(1): 64. doi: 10.1186/s43162-023-00243-y
  6. Ma RCW. Genetics of cardiovascular and renal complications in diabetes. J Diabetes Investig 2016; 7(2): 139-54. doi: 10.1111/jdi.12391 PMID: 27042264
  7. Nagaraj BS, Pena MJ, Ju W, Heerspink HL. Machine-learning–based early prediction of end-stage renal disease in patients with diabetic kidney disease using clinical trials data. Diabetes Obes Metab 2020; 22(12): 2479-86. doi: 10.1111/dom.14178 PMID: 32844582
  8. Hu Q, Jiang L, Yan Q, Zeng J, Ma X, Zhao Y. A natural products solution to diabetic nephropathy therapy. Pharmacol Ther 2023; 241: 108314. doi: 10.1016/j.pharmthera.2022.108314 PMID: 36427568
  9. Shayakul C, Teeraboonchaikul R, Susomboon T, Kulabusaya B, Pudchakan P. Medication adherence, complementary medicine usage and progression of diabetic chronic kidney disease in thais. Patient Prefer Adherence 2022; 16: 467-77. doi: 10.2147/PPA.S350867 PMID: 35221676
  10. Ansari P, Akther S, Hannan JMA, Seidel V, Nujat NJ, Abdel-Wahab YHA. Pharmacologically active phytomolecules isolated from traditional antidiabetic plants and their therapeutic role for the management of diabetes mellitus. Molecules 2022; 27(13): 4278. doi: 10.3390/molecules27134278 PMID: 35807526
  11. Sun G, Li C, Cui W, et al. Review of herbal traditional Chinese medicine for the treatment of diabetic nephropathy. J Diabetes Res 2016; 2016: 5749857. doi: 10.1155/2016/5749857
  12. Khosnutdinova TS, Gemejiyeva NG, Karzhaubekova ZZ, Sultanova NA. Coumarins of genus Ferula L. (Apiaceae Lindl.). Eurasian Chem-Technol J 2023; 25(1): 39-56. doi: 10.18321/ectj1494
  13. Khojimatov OK, Bussmann RW. Ferula assa-foetida L., Ferula foetida (Bunge) Regel, Ferula foetidissima Regel & Schmalh., Ferula karelinii Bunge, Ferula kuhistanica Korovin, Ferula moschata. (H. Reinsch) Koso-Pol., Ferula tadshikorum Pimenov, Ferula tenuisecta Korovin, Ferula varia (Sc. Ethnobiology of Uzbekistan: Ethnomedicinal Knowledge of Mountain Communities. Springer 2023; pp. 359-71. doi: 10.1007/978-3-031-23031-8_36
  14. Ghavi F, Shakeri F, Taebi M. Effects of Ferula assa-foetida on clinical, hormonal and sonography parameters in young girls with polycystic ovary syndrome: Pilot randomized, placebo controlled, triple-blinded. Research Square 2020. doi: 10.21203/rs.3.rs-37218/v2
  15. Farhadi F, Iranshahi M, Taghizadeh SF, Asili J. Volatile sulfur compounds: The possible metabolite pattern to identify the sources and types of asafoetida by headspace GC/MS analysis. Ind Crops Prod 2020; 155: 112827. doi: 10.1016/j.indcrop.2020.112827
  16. Eidi S, Iranshahi M, Mohammadinejad A, Mohsenzadeh MS, Farhadi F, Mohajeri SA. Selective isolation of sesquiterpene coumarins from asafoetida using dummy molecularly imprinted solid phase extraction method. J Chromatogr B Analyt Technol Biomed Life Sci 2020; 1138: 121943. doi: 10.1016/j.jchromb.2019.121943 PMID: 31911205
  17. Bagheri SM, Hakimizadeh E, Allahtavakoli M. A review on antidiabetic potential of genus Ferula (Apiaceae). Curr Tradit Med 2024; 10(1): e090323214509. doi: 10.2174/2215083809666230309111323
  18. Azari M, Mohiti-ardekani J, Abedini S, Mozayan MR. Effect of Ferula assafoetida on cytoplasmic membrane glucose transporter isotype-4 of C2C12 cell line. Int J Med Lab 2014; 1: 46-53.
  19. Iranshahi M, Alizadeh M. Antihyperglycemic effect of Asafoetida (Ferula assafoetida Oleo-Gum-Resin) in streptozotocin-induced diabetic rats. World Appl Sci J 2012; 17: 157-62.
  20. Znati M, Ben Jannet H, Cazaux S, Souchard J, Skhiri HGF, Bouajila J. Antioxidant, 5-lipoxygenase inhibitory and cytotoxic activities of compounds isolated from the Ferula lutea flowers. Molecules 2014; 19(10): 16959-75. doi: 10.3390/molecules191016959 PMID: 25340301
  21. Iranshahy M, Iranshahi M. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-A review. J Ethnopharmacol 2011; 134(1): 1-10. doi: 10.1016/j.jep.2010.11.067 PMID: 21130854
  22. Kandhare AD, Mukherjee A, Bodhankar SL. Antioxidant for treatment of diabetic nephropathy: A systematic review and meta-analysis. Chem Biol Interact 2017; 278: 212-21. doi: 10.1016/j.cbi.2017.10.031 PMID: 29108777
  23. Yaribeygi H, Atkin SL, Simental-Mendía LE, Barreto GE, Sahebkar A. Anti-inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways. J Cell Physiol 2019; 234(9): 14873-82. doi: 10.1002/jcp.28315 PMID: 30746696
  24. Wang L, Wang H, Lan H. TGF-β signaling in diabetic nephropathy: An update. Diabet Nephrop 2022; 2(1): 7-16. doi: 10.2478/dine-2022-0011
  25. Anvari M, Yadegari M, Porentezari M, et al. Effect of Ferula assa-foetida oleo gum resin on spermatic parameters and testicular histopathology in male wistar rats. J Ayurveda Integr Med 2015; 6(3): 175-80. doi: 10.4103/0975-9476.146552 PMID: 26604552
  26. Zhang M, Lv X-Y, Li J, Xu Z-G, Chen L. The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res 2008; 2008: 704045. doi: 10.1155/2008/704045
  27. Ahmad U, Ahmad RS. Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats. BMC Complement Altern Med 2018; 18(1): 179. doi: 10.1186/s12906-018-2245-2 PMID: 29890969
  28. Bagheri SM, Yadegari M, Behpur M, Javidmehr D. Antilithiatic and hepatoprotective effects of Ferula assa-foetida oleo-gum-resin on ethylene glycol-induced lithiasis in rats. Urol Sci 2018; 29(4): 180-5. doi: 10.4103/UROS.UROS_10_18
  29. Shieh A, Bagheri SM, Yadegari M, Javidmehr D, Farhadi Z. Therapeutic effect of Ferula assa-foetida oleo-gum resin in rats with letrozole-induced polycystic ovary syndrome. Clin Exp Reprod Med 2022; 49(4): 239-47. doi: 10.5653/cerm.2022.05449 PMID: 36482498
  30. Sagoo MK, Gnudi L. Diabetic nephropathy: An overview. Methods Mol Biol 2020; 2067: 3-7. doi: 10.1007/978-1-4939-9841-8_1
  31. Zhang X-X, Kong J, Yun K. Prevalence of diabetic nephropathy among patients with type 2 diabetes mellitus in China: A meta-analysis of observational studies. J Diabetes Res 2020; 2020: 2315607. doi: 10.1155/2020/2315607
  32. DeFronzo RA, Reeves WB, Awad AS. Pathophysiology of diabetic kidney disease: Impact of SGLT2 inhibitors. Nat Rev Nephrol 2021; 17(5): 319-34. doi: 10.1038/s41581-021-00393-8 PMID: 33547417
  33. Soria B, Skoudy A, Martín F. From stem cells to beta cells: New strategies in cell therapy of diabetes mellitus. Diabetologia 2001; 44(4): 407-15. doi: 10.1007/s001250051636 PMID: 11357469
  34. Bagheri S, Yadegari M, Mirjalily A, Rezvani M. Evaluation of toxicity effects of asafetida on biochemical, hematological, and histological parameters in male wistar rats. Toxicol Int 2015; 22(1): 61-5. doi: 10.4103/0971-6580.172258 PMID: 26862262
  35. Abu-Zaiton AS. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pak J Biol Sci 2010; 13(2): 97-100. doi: 10.3923/pjbs.2010.97.100 PMID: 20415145
  36. Esmailidehaj M, Kahtenaroon M, Rezvani ME, Azizian H, Ranjbar A. Enriched-asafoetida diet attenuates hyperglycemia, oxidative stress and endothelial dysfunction in type 2 diabetic rats. Physiol Pharmacol 2022; 26(1): 7-19. doi: 10.52547/phypha.26.1.8
  37. Latifi E, Mohammadpour AA, Hafshejani FB, Nourani H. Ferula assa-foetida oleo gum resin ethanolic extract alleviated the pancreatic changes and antioxidant status in Streptozotocin-induced diabetic rats: A biochemical, histopathological, and ultrastructural study. J Food Biochem 2022; 46(8): e14191. doi: 10.1111/jfbc.14191 PMID: 35474229
  38. Latifi E, Mohammadpour AA, H BF, Nourani H. Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats. Biomed Pharmacother 2019; 110: 197-202. doi: 10.1016/j.biopha.2018.10.152 PMID: 30471513
  39. Podkowińska A, Formanowicz D. Chronic kidney disease as oxidative stress-and inflammatory-mediated cardiovascular disease. Antioxidants 2020; 9(8): 752. doi: 10.3390/antiox9080752 PMID: 32823917
  40. Charlton A, Garzarella J, Dahm JKAM, Jha JC. Oxidative stress and inflammation in renal and cardiovascular complications of diabetes. Biology 2020; 10(1): 18. doi: 10.3390/biology10010018 PMID: 33396868
  41. Rahmani AH, Alsahli MA, Khan AA, Almatroodi SA. Quercetin, a plant flavonol attenuates diabetic complications, renal tissue damage, renal oxidative stress and inflammation in Streptozotocin-induced diabetic rats. Metabolites 2023; 13(1): 130. doi: 10.3390/metabo13010130 PMID: 36677055
  42. Niazmand R, Razavizadeh BM. Ferula asafoetida: Chemical composition, thermal behavior, antioxidant and antimicrobial activities of leaf and gum hydroalcoholic extracts. J Food Sci Technol 2021; 58(6): 2148-59. doi: 10.1007/s13197-020-04724-8 PMID: 33967312
  43. Mobasheri L, Khorashadizadeh M, Safarpour H, Mohammadi M, Sarab AG, Askari VR. Anti-inflammatory activity of Ferula assafoetida oleo-gum-resin (Asafoetida) against TNF-α-stimulated human umbilical vein endothelial cells (HUVECs). Mediators Inflamm 2022; 2022: 5171525.
  44. Bagheri SM, Hedesh ST, Mirjalili A, Dashti-R MH. Evaluation of anti-inflammatory and some possible mechanisms of antinociceptive effect of Ferula assa foetida oleo gum resin. J Evid Based Complementary Altern Med 2016; 21(4): 271-6. doi: 10.1177/2156587215605903 PMID: 26427790
  45. Amalraj A, Gopi S. Biological activities and medicinal properties of Asafoetida: A review. J Tradit Complement Med 2017; 7(3): 347-59. doi: 10.1016/j.jtcme.2016.11.004 PMID: 28725631
  46. Wu H, Xu F, Huang X, et al. Lupenone improves type 2 diabetic nephropathy by regulating NF-κB pathway-mediated inflammation and TGF-β1/Smad/CTGF-associated fibrosis. Phytomedicine 2023; 118: 154959. doi: 10.1016/j.phymed.2023.154959 PMID: 37478684
  47. Kadhim SH, Khakzad MR, Eshaghi A. Evaluation of the relationship between tgf-B expression and clinical symptoms in patients with diabetic nephropathy. J Pharm Negat Results 2023; 14: 211-26.
  48. Gomes BK, Rodrigues FK, Fernandes AP. The role of transforming growth factor-beta in diabetic nephropathy. Int J Med Genet 2014; 2014: 1-6. doi: 10.1155/2014/180270

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Bentham Science Publishers