Nanofabrication of Losartan Potassium Sustained Release Floating Microspheres using Different Grades of Ethyl Cellulose and its Insight on Release Profiles


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Abstract

Introduction:A sustained release system for losartan potassium designed to delay its residence time in the stomach through the preparation of solvent evaporation technique-based floating microspheres. The influence of the different grades of Ethocel™ such as 4 cps, 10 cps, and 22 cps as well as the drug: polymer ratio on various properties of microspheres were tested.

Methods:Thermal and functional analysis revealed no interaction between the encapsulated drug and polymer. The results indicated that the mean diameter of microspheres increased with a change in grades of ethyl cellulose relating to viscosity. However, the drug incorporation efficiency within ethyl cellulose microspheres decreased with increasing viscosity of ethyl cellulose.

Results:The bulk density of the formulations was proportionally dependent on concentration and the viscosity of the polymer, which resulted in a decrease in floating capacity from 90.02% to 73.58%. Moreover, the drug release was indirectly proportional to the viscosity of ethyl cellulose tested. The in vitro release profile exhibited a burst effect with a biphasic release pattern following Fickian diffusion, indicating a diffusioncontrolled release mechanism.

Conclusion:The results demonstrated that the viscosity of ethyl cellulose significantly affects the floating capacity and drug release pattern from microspheres.

About the authors

Tanavirsing Rajput

Department of Pharmaceutical Technology,, St. John Institute of Pharmacy and Research

Email: info@benthamscience.net

Popat Mohite

Department of Pharmaceutical Technology,, St. John Institute of Pharmacy and Research

Email: info@benthamscience.net

Santosh Ghule

Department of Pharmaceutics, Savitribai Phule Pune University

Email: info@benthamscience.net

Kuldeep Vinchurkar

Department of Pharmaceutics and Pharmaceutical Technology, Krishna School of Pharmacy and Research, Krishna School of Emerging Technology and Applied Research,, Drs. Kiran and Pallavi Patel Global Univeristy (KPGU)

Email: info@benthamscience.net

Sudarshan Singh

Faculty of Pharmacy,, Chiang Mai University

Author for correspondence.
Email: info@benthamscience.net

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