The Effect of Ginseng Supplementation on Lipid Profile: GRADE-assessed Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials


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Abstract

Background:This systematic review and meta-analysis aimed to evaluate the overall impact of Panax ginseng on lipid profile by synthesizing existing evidence. Cardiovascular Disease (CVD) is the leading cause of morbidity and mortality among the elderly population, and serum lipids play a crucial role in its development. Maintaining optimal levels of triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total cholesterol is essential in reducing the risk of CVD. Ginsenosides, the active constituents in ginseng, have shown positive effects on lipid metabolism. This review aimed to provide a comprehensive understanding of the potential benefits of ginseng in managing dyslipidemia, which could have significant implications for the prevention and treatment of CVD.

Methods:A comprehensive analysis of 29 Randomized Controlled Trials (RCTs) was conducted to assess the effects of ginseng supplementation on lipid profile, including Triglyceride (TG), Total Cholesterol (TC), High-density Lipoprotein Cholesterol (HDL-C), and Low-density Lipoprotein Cholesterol (LDL-C) levels. A systematic search was done in online databases, such as MEDLINE, Scopus, and Clarivate Analytics Web of Science, using relevant keywords and MeSH terms to identify relevant studies until January 2024.

Results:The Weighted Mean Differences (WMD) and 95% Confidence Intervals (CI) for TG, TC, LDL-C, and HDL-C did not show significant changes with ginseng supplementation.

Conclusion:Taking into account the results, using ginseng did not have a statistically significant influence on lipid profile parameters in individuals with different health conditions. Further, well-designed RCTs focusing on specific diseases are needed to clarify the potential beneficial effects of ginseng and its derivatives on lipid profile.

About the authors

Seyyed Arabi

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences

Email: info@benthamscience.net

Mostafa Shahraki-Jazinaki

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Maryam Nayyer Abadi

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences

Email: info@benthamscience.net

Leila Bahrami

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences

Email: info@benthamscience.net

Mahla Chambari

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences

Email: info@benthamscience.net

Hossein Bahari

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Amirhossein Sahebkar

Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University

Author for correspondence.
Email: info@benthamscience.net

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