MicroRNAs as Key Regulators in RA and SLE: Insights into Biological Functions


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Abstract

MicroRNAs (miRNAs) are non-coding RNA molecules that bind to mRNAs to regulate gene expression. Since changes in miRNA expression levels have been found in a variety of autoimmune illnesses, miRNAs are important in autoimmune diseases. MiRNAs serve not only as pathogenic factors and biomarkers for autoimmune diseases but also as important targets for disease therapeutics. Although miRNA-based treatments are still in the research stage, in-depth investigations into the biological functions of miRNAs have significantly enhanced our understanding of their mechanisms in autoimmune diseases. The purpose of this review is to summarize the biological functions of miRNAs, their roles in rheumatoid arthritis and systemic lupus erythematosus, therapeutic strategies, and challenges.

About the authors

Xiao-Xiao Li

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Email: info@benthamscience.net

Chan-Na Zhao

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Email: info@benthamscience.net

Hai-Fen Wei

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Email: info@benthamscience.net

Sheng Li

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Email: info@benthamscience.net

Jian Tang

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Email: info@benthamscience.net

Yan-Yu Zhu

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Email: info@benthamscience.net

Xue-Er Cheng

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Email: info@benthamscience.net

Qian-Qian Shi

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Email: info@benthamscience.net

Peng Wang

Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University

Author for correspondence.
Email: info@benthamscience.net

Hai-Feng Pan

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University

Author for correspondence.
Email: info@benthamscience.net

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