Advancing Novel Strategies against Post-surgical Tendon Adhesion Bands, Exploring New Frontiers


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Abstract

Current interest in adhesion formation stems from its global impact on the function and quality of life, spanning a spectrum of subtle impairments to significant disabilities, based on the affected area and the extent of adhesion. Yet therapeutic agents are restricted to prophylactic anti-inflammatories, revision surgeries, and biological and physical techniques, none of which grant a decent outcome. Recent advancements in tissue- engineered biomaterials, drug delivery systems, and fabricating technologies such as nanoparticles, hydrogels, and weaving or braiding demonstrate potential for improved outcomes. However, none of the mentioned methods have reliable outcomes, thus this study aims to elucidate the mechanisms involved in the pathophysiology of tendon adhesion and post-surgical adhesion band formation (PSAB), with a closer look at inflammatory pathways stimulating the process. This article consolidates information on diverse therapeutic and prophylactic methods and cutting-edge technologies, aiming to provide a comprehensive update on this topic, and providing researchers an avenue for new and innovative ideas for further investigations.

About the authors

Maryam Alaei

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Doaa Abdulhasan

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Amirhossein Barjasteh

Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Abdulridha Al-Asady

Department of Medical Sciences, Faculty of Nursing, Warith Al-Anbiyaa University

Email: info@benthamscience.net

Hanieh Latifi

Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Ehsan Vahedi

Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Amir Avan

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Majid Khazaei

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Mikhail Ryzhikov

School of Medicine, Saint Louis University

Email: info@benthamscience.net

Seyed Hassanian

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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