Comprehensive Overview of Innovative Strategies in Preventing Renal Ischemia-reperfusion Injury: Insights from Bibliometric and In silico Analyses
- Authors: Rysmakhanov M.1, Zare A.2, Smagulov A.1, Abenova N.3, Mussin N.4, Sultangereyev Y.4, Zhakiyev B.4, Kuttymuratov G.5, Haberal M.6, Jafari N.2, Baneshi H.2, Bakhshalizadeh S.7, Mahdipour M.8, Rahmanifar F.9, Tamadon A.10
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Affiliations:
- Department of Surgery and Urology No. 2,, West Kazakhstan Marat Ospanov State Medical University
- , PerciaVista R&D Co.
- Department of General Medical Practice No. 1, West Kazakhstan Medical University
- Department of Surgery and Urology No. 2, West Kazakhstan Medical University
- Department of Surgery and Transplantation,, Aktobe Medical Center
- Department of General Surgery, Division of Transplantation,, Başkent University
- Reproductive Development, Murdoch Children's Research Institute
- Stem Cell Research Center, Tabriz University of Medical Sciences
- Department of Basic Sciences, School of Veterinary Medicine,, Shiraz University
- Department of Surgery and Transplantation, Aktobe Medical Center
- Issue: Vol 30, No 20 (2024)
- Pages: 1578-1598
- Section: Immunology, Inflammation & Allergy
- URL: https://vestnikugrasu.org/1381-6128/article/view/645761
- DOI: https://doi.org/10.2174/0113816128283420240409050754
- ID: 645761
Cite item
Full Text
Abstract
Background:Ischemia-Reperfusion Injury (IRI) is a complex pathophysiological process with severe consequences, including irreversible loss of renal function. Various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and kidney reperfusion.
Aim:This comprehensive analysis provides an overview of pharmacological agents and intraoperative methods for preventing and treating renal IRI.
Methods:Our analysis revealed that eplerenone exhibited the highest binding affinity to crucial targets, including Aldehyde Dehydrogenase (AD), Estrogen Receptor (ER), Klotho protein, Mineralocorticoid Receptor (MR), and Toll-like Receptor 4 (TLR4). This finding indicates eplerenone's potential as a potent preventive agent against IRI, surpassing other available therapeutics like Benzodioxole, Hydrocortisone, Indoles, Nicotinamide adenine dinucleotide, and Niacinamide. In preventing kidney IRI, our comprehensive analysis emphasizes the significance of eplerenone due to its strong binding affinity to key targets involved in the pathogenesis of IRI.
Results:This finding positions eplerenone as a promising candidate for further clinical investigation and consideration for future clinical practice.
Conclusion:The insights provided in this analysis will assist clinicians and researchers in selecting effective preventive approaches for renal IRI in surgical settings, potentially improving patient outcomes.
About the authors
Myltykbay Rysmakhanov
Department of Surgery and Urology No. 2,, West Kazakhstan Marat Ospanov State Medical University
Author for correspondence.
Email: info@benthamscience.net
Afshin Zare
, PerciaVista R&D Co.
Email: info@benthamscience.net
Aibolat Smagulov
Department of Surgery and Urology No. 2,, West Kazakhstan Marat Ospanov State Medical University
Email: info@benthamscience.net
Nurgul Abenova
Department of General Medical Practice No. 1, West Kazakhstan Medical University
Email: info@benthamscience.net
Nadiar Mussin
Department of Surgery and Urology No. 2, West Kazakhstan Medical University
Email: info@benthamscience.net
Yerlan Sultangereyev
Department of Surgery and Urology No. 2, West Kazakhstan Medical University
Email: info@benthamscience.net
Bazylbek Zhakiyev
Department of Surgery and Urology No. 2, West Kazakhstan Medical University
Email: info@benthamscience.net
Gani Kuttymuratov
Department of Surgery and Transplantation,, Aktobe Medical Center
Email: info@benthamscience.net
Mehmet Haberal
Department of General Surgery, Division of Transplantation,, Başkent University
Email: info@benthamscience.net
Nazanin Jafari
, PerciaVista R&D Co.
Email: info@benthamscience.net
Hanieh Baneshi
, PerciaVista R&D Co.
Email: info@benthamscience.net
Shabnam Bakhshalizadeh
Reproductive Development, Murdoch Children's Research Institute
Email: info@benthamscience.net
Mahdi Mahdipour
Stem Cell Research Center, Tabriz University of Medical Sciences
Email: info@benthamscience.net
Farhad Rahmanifar
Department of Basic Sciences, School of Veterinary Medicine,, Shiraz University
Email: info@benthamscience.net
Amin Tamadon
Department of Surgery and Transplantation, Aktobe Medical Center
Email: info@benthamscience.net
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