Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights


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Resumo

Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these markersCancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate understanding and stimulate further research for developing effective diagnostic and therapeutic strategies in CRC.

Sobre autores

Atena Soleimani

Department of Biochemistry,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Nikoo Saeedi

Medical School, Islamic Azad University,

Email: info@benthamscience.net

Abdulridha Al-Asady

Department of Pharmacology, University of Warith Al-Anbiyaa

Email: info@benthamscience.net

Elnaz Nazari

Department of Physiology, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Reyhane Hanaie

Department of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Majid Khazaei

Department of Physiology, Mashhad University of Medical Sciences,

Email: info@benthamscience.net

Elnaz Ghorbani

Department of Microbiology,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Hamed Akbarzade

Department of Biochemistry,, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Mikhail Ryzhikov

Department of Biochemistry, Saint Louis University

Email: info@benthamscience.net

Amir Avan

Department of Genetics, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Seyed Mehr

Department of Biochemistry, Mashhad University of Medical Sciences

Autor responsável pela correspondência
Email: info@benthamscience.net

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