Practical Successes of Laboratory Evolution

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Adaptive Laboratory Evolution (ALE) represents a novel methodology for the generation of microbial strains with desired characteristics and the production of value-added products. Additionally, ALE is employed as a means of enhancing comprehension of the genetic and/or metabolic pathways of evolution. The objective of this review is to analyze the results of studies that elucidate and demonstrate the potential of microorganisms as model objects for laboratory evolutionary experiments. These experiments are becoming increasingly prevalent in the study of adaptation, the evaluation of evolutionary dynamics, and the testing of various evolutionary hypotheses. Concurrently, ALE has demonstrated itself to be a promising and efficacious methodology, which, when employed for biotechnological applications, has already resulted in the generation of novel and useful microbial strains. It is important to note that the current successes not only demonstrate the power and versatility of this approach but also highlight a number of unanswered questions. The conclusions drawn on the basis of ALE require a cautious interpretation of the results obtained.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Y. Dunaevsky

Lomonosov Moscow State University

Хат алмасуға жауапты Автор.
Email: dun@belozersky.msu.ru

Belozersky Institute of Physico-Chemical Biology

Ресей, Moscow, 119991

O. Kudryavtseva

Lomonosov Moscow State University

Email: dun@belozersky.msu.ru

Biological Faculty

Ресей, Moscow, 119991

S. Agroskin

Lomonosov Moscow State University

Email: dun@belozersky.msu.ru

Biological Faculty

Ресей, Moscow, 119991

A. Gasparyan

Lomonosov Moscow State University

Email: dun@belozersky.msu.ru

Biological Faculty

Ресей, Moscow, 119991

M. Belozersky

Lomonosov Moscow State University

Email: dun@belozersky.msu.ru

Belozersky Institute of Physico-Chemical Biology

Ресей, Moscow, 119991

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