Роль LIM-киназы 1 в процессах памяти

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Аннотация

Согласно современным представлениям, основу интеллектуальных проблем при нейрологических повреждениях мозга составляет активное забывание, регулируемое зависимыми от малых ГТФаз Rac и Rho сигнальными каскадами ремоделирования актина. Ключевой фермент этих каскадов – LIM-киназа 1 (LIMK1). Изменения экспрессии гена limk1 приводят к нейрокогнитивным патологиям. Для экспресс-скрининга и тестирования агентов целенаправленного терапевтического воздействия, изменяющих белок-белковые взаимодействия ГТФаз и компонентов сигнальных каскадов, необходимо создание и валидация простых животных моделей. Такую возможность предоставляет дрозофила, мутантные линии которой позволяют выявить узловые моменты пересечений биохимических и нервных сетей, сопровождающие активное забывание.

Об авторах

Е. А. Никитина

Институт физиологии им. И.П. Павлова РАН; Российский государственный педагогический университет им. А.И. Герцена

Автор, ответственный за переписку.
Email: 21074@mail.ru
Россия, 199034, Санкт-Петербург; Россия, 191186, Санкт-Петербург

Е. С. Заломаева

Институт физиологии им. И.П. Павлова РАН; Российский государственный педагогический университет им. А.И. Герцена

Автор, ответственный за переписку.
Email: Zalomaeva.E@yandex.ru
Россия, 199034, Санкт-Петербург; Россия, 191186, Санкт-Петербург

А. В. Медведева

Институт физиологии им. И.П. Павлова РАН

Автор, ответственный за переписку.
Email: avmed56@mail.ru
Россия, 199034, Санкт-Петербург

А. В. Журавлев

Институт физиологии им. И.П. Павлова РАН

Автор, ответственный за переписку.
Email: beneor@mail.ru
Россия, 199034, Санкт-Петербург

Е. В. Савватеева-Попова

Институт физиологии им. И.П. Павлова РАН

Автор, ответственный за переписку.
Email: esavvateeva@mail.ru
Россия, 199034, Санкт-Петербург

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